Vitamin K could lower the risk of cardiovascular disease, UWA finds

vitamin K

Researchers from the University of Western Australia (UWA) and Edith Cowan University have found that people who eat a diet rich in vitamin K could have a 34 per cent lower risk of atherosclerosis-related cardiovascular disease. 

The team examined data from over 50,000 people taking part in the Danish Diet, Cancer and Health study over 23 years. They investigated whether people who ate more foods containing vitamin K had a lower risk of cardiovascular disease related to atherosclerosis (plaque build-up in the arteries). 

There are two types of vitamin K found in food. Vitamin K1 comes primarily from green leafy vegetables and vegetable oils, while vitamin K2 is found in meat, eggs and fermented foods such as cheese. 

The study found that people with the highest intakes of vitamin K1 were 21 per cent less likely to be hospitalised with cardiovascular disease related to atherosclerosis. For vitamin K2, the risk of being hospitalised was 14 per cent lower.  

This lower risk was seen for all types of heart disease related to atherosclerosis, particularly for peripheral artery disease at 34 per cent. 

UWA researcher Dr Jamie Bellinge, a co-author on the study, said the role of vitamin K in cardiovascular health and particularly in vascular calcification is an area of research offering promising hope for the future. 

“Cardiovascular disease remains a leading cause of death in Australia and there’s still a limited understanding of the importance of different vitamins found in food and their effect on heart attacks, strokes and peripheral artery disease,” Bellinge said. 

“These findings shed light on the potentially important effect that vitamin K has on the killer disease and reinforces the importance of a healthy diet in preventing it.” 

The results suggest that consuming more vitamin K may be important for protection against atherosclerosis and subsequent cardiovascular disease. 

“Current dietary guidelines for the consumption of vitamin K are generally only based on the amount of vitamin K1 a person should consume to ensure that their blood can coagulate,” ECU researcher Dr Nicola Bondonno said. 

“However, there’s growing evidence that intakes of vitamin K above the current guidelines can afford further protection against the development of other diseases, such as atherosclerosis. 

“Although more research is needed to fully understand the process, we believe that vitamin K works by protecting against the calcium build-up in the major arteries of the body.” 

The next phase of the research will involve developing and improving databases on the vitamin K2 content of foods. 

“There are 10 forms of vitamin K2 found in our diet and each of these may be absorbed and act differently within our bodies,” Bondonno said. 

“The next phase of the research will involve developing and improving databases on the vitamin K2 content of foods. 

“More research into the different dietary sources and effects of different types of vitamin K2 is a priority.” 

The paper “Vitamin K intake and atherosclerotic cardiovascular disease in the Danish Diet Cancer and Health Study” was published in the Journal of the American Heart Association. 


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